Hydrochloric Acid → 3-Bromoacetyloxymethyl-5,5-diphenyl-2,4-imidazolidinedione

HRID 359865ノート

反応式

HRID 359865 の反応式
[C:1]1([C:7]2([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[NH:11][C:10](=[O:12])[N:9]([CH2:13][OH:14])[C:8]2=[O:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:22][CH2:23][C:24](Cl)=[O:25].Cl>C(OCC)C>[Br:22][CH2:23][C:24]([O:14][CH2:13][N:9]1[C:8](=[O:15])[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:11][C:10]1=[O:12])=[O:25]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 89602Bromoacetyl chlorideHCID 1613663-(Hydroxymethyl)phenytoin

生成物 1

HCID 147506983-Bromoacetyloxymethyl-5,5-diphenyl-2,4-imidazolidinedione

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

5,5-Diphenyl-3-hydroxymethyl-2,4-imidazolidinedione (2 g, 0.0071 mol) was dissolved in bromoacetylchloride (15 g, 8 mL, 0.096 mol) by heating in an oil bath (70°-80° C. bath temperature) for about 15 minutes, until the formation of HCl ceased. The mixture was cooled and 30 mL of ethyl ether were added. White crystals formed. The mixture was cooled to 0° C., then the crystals were removed by filtration and dried over P2O5. Yield: 2.15 g (75%), m.p. 179°-183° C. Anal. calc. for C18H15N2O4Br: C, 53.61, H, 3.75; N, 6.95; Br, 19.82. Found: C, 53.60; H, 3.79; N, 6.92; Br, 19.90. The product had the formula: ##STR75##

後処理

  1. temperatureby heating in an oil bath (70°-80° C. bath temperature) for about 15 minutes
  2. temperatureThe mixture was cooled
  3. customWhite crystals formed
  4. customthe crystals were removed by filtration
  5. dry with materialdried over P2O5

出典と根拠

ORDレコード
ord-3a825cfd58de44ef942f6ae2a49974a2
出典データセット
uspto-grants-1991_03
特許番号
US05002935

反応ノート

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