化工社化工社 化学情報印刷レポート · 研究参考用
Ethanolamine → N-(2-hydroxyethyl)nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | Ethyl Nicotinate | HCID 69188 | — |
| 生成物 | N-(2-hydroxyethyl)nicotinamide | HCID 72663 | 85.1% |
反応手順
A solution of 49.2 g (0.32525 mol) ethyl nicotinate and 72 g (1.17 mol) ethanolamine was heated at 70° C. for 60 hours. The excess ethanolamine was removed under reduced pressure and the resulting viscous cream oil was stirred with ether for 48 hours. The resulting white solid was removed by filtration, affording 46 g (85.1%) of the title compound melting at 75°-78° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05002935 |
| 出典データセット | uspto-grants-1991_03 |
| ORD ID | ord-d75f9f418ccc4c9a9128f3b7711a460b |
| 出典メモ | uspto-grants-1991_03 |