Tridecane → 3,4-Difluorobenzoic acid
反応式
[F:1][C:2]1[CH:3]=[C:4]([C:12]([OH:14])=[O:13])[C:5](=[CH:9][C:10]=1[F:11])C(O)=O.CCCCCCCCCCCCC>CN1CCCC1=O>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:9][C:10]=1[F:11])[C:12]([OH:14])=[O:13]参加物
4
反応条件
- 温度
- 190 °C
実験手順
4,5-difluorophthalic acid (0.55 grams, 2.7 mmole) was added to a slurry of cupric oxide (10% by weight of starting material) in 5 ml. of N-methyl-2-pyrrolidone solvent. n-tridecane (0.25 grams) was added as an internal standard. The mixture was heated to 190° C. for 3 hours, at which time GC analysis indicated complete consumption of the starting material and conversion to 3,4-difluorobenzoic acid in an 87% yield, based upon the internal standard, corrected for response factors.
後処理
- customconsumption of the starting material and conversion to 3,4-difluorobenzoic acid in an 87% yield
出典と根拠
- ORDレコード
- ord-fcfd1f5b2bce4b5b97698e30056690df
- 出典データセット
- uspto-grants-1991_03
- 特許番号
- US05003103
反応ノート
読み込み中…