Terazosin Hydrochloride → 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate

HRID 35999

反応式

HRID 35999 の反応式
O.O.[ClH:3].[NH2:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:17][CH3:18])=[C:12]([O:15][CH3:16])[CH:13]=2)[N:8]=[C:7]([N:19]2[CH2:24][CH2:23][N:22]([C:25]([CH:27]3[CH2:31][CH2:30][CH2:29][O:28]3)=[O:26])[CH2:21][CH2:20]2)[N:6]=1>CO>[CH3:12][O-:15].[ClH:3].[NH2:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:17][CH3:18])=[C:12]([O:15][CH3:16])[CH:13]=2)[N:8]=[C:7]([N:19]2[CH2:24][CH2:23][N:22]([C:25]([CH:27]3[CH2:31][CH2:30][CH2:29][O:28]3)=[O:26])[CH2:21][CH2:20]2)[N:6]=1

参加物

3

反応物 1

HCID 63016Terazosin Hydrochloride

生成物 1

HCID 867486641-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate収率 87%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride dihydrate (7.37. g, 16.0 mmol, prepared in accordance with the teachings of U.S. Pat. No. 4,25 1,532) was placed in an Edenmeyer flask and dissolved in a minimum amount (about 10 mL) of hot dry methanol. The solid initially dissolved, but soon turned cloudy and a precipitate formed. The precipitate was collected by filtration and washed with a small quantity of dry methanol followed by dry acetone to yield 6.35 g (13.9 mmol, 87.0%) of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate.

後処理

  1. customg, 16.0 mmol, prepared in accordance with the teachings of U.S
  2. dissolutionThe solid initially dissolved
  3. customa precipitate formed
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with a small quantity of dry methanol

出典と根拠

ORDレコード
ord-0d1412ab4e3b409890ef460da4092292
出典データセット
uspto-grants-1995_05
特許番号
US05412095

関連ノート

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