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Methanethiol → Ethyl 2-butyl-1-[[2'-(methoxycarbonyl)-(1,1'-biphenyl)-4-yl]-methyl]-4-(methylthio)-1H-imidazole-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanethiol | HCID 878 | — |
| 反応物 | Ethyl 2-butyl-5-methylsulfanyl-3H-imidazole-4-carboxylate | HCID 9859628 | — |
| 反応物 | Methyl 4'-(bromomethyl)biphenyl-2-carboxylate | HCID 11012181 | — |
| 生成物 | Ethyl 2-butyl-1-[[2'-(methoxycarbonyl)-(1,1'-biphenyl)-4-yl]-methyl]-4-(methylthio)-1H-imidazole-5-carboxylate | HCID 21479063 | 69.3% |
反応手順
The operation is carried out as in Example 5, starting with 0.6 g of ethyl 2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate (prepared as indicated in Stages C and D of Preparation 1, replacing the ethanethiol with methanethiol), using 907 mg of methyl 4'-(bromomethyl)-(1,1'-biphenyl)-2 -carboxylate. After chromatography on silica (eluant: methylene chloride--ethyl acetate (97-3)), 0.8 g of the desired product is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05412101 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-473075b184e64b86bdfbb71dc68452bf |
| 出典メモ | uspto-grants-1995_05 |