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Methanol → Methyl 4-bromobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 4-Bromobenzoic acid | HCID 11464 | — |
| 生成物 | Methyl 4-bromobenzoate | HCID 12081 | 87.5% |
反応手順
4-Bromobenzoic acid (9.98 kg, 48 mol) was suspended in 40 kg of methanol. Sulfuric acid (2 kg, 20 mol) was added and the mixture was heated under reflux for approximately 5 hours. The mixture was cooled over 10 hours to -10° C. and allowed to stand for 5 hours giving a crystalline product. The product was isolated by filtration and the filter cake was washed with methanol (2×3 L). Drying gave methyl 4-bromobenzoate (9.97 kg, 42 mol), m.p. 78°-78.7° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05412102 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-bd225c2486bf4e2c8393dcbbeb4f722c |
| 出典メモ | uspto-grants-1995_05 |