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Water → (4-Bromobenzylidene)(1-isopropyl-2-methylpropyl)amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4-Bromobenzaldehyde | HCID 70741 | — |
| 反応物 | 3-Pentanamine, 2,4-dimethyl- | HCID 77702 | — |
| 触媒 | p-Toluenesulfonic acid | HCID 6101 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | (4-Bromobenzylidene)(1-isopropyl-2-methylpropyl)amine | HCID 15225580 | 94.9% |
反応手順
A mixture of 4-bromobenzaldehyde (7.3 g, 40.0 mmol), 2,4-dimethylpent-3-ylamine (4.8 g, 41.4 mmol), and para-toluenesulfonic acid (0.05 g, 0.29 mmol) in 125 mL of toluene was heated under reflux while water was removed with a Dean-Stark trap. The toluene then was removed under vacuum and distillation of the remaining residue gave (4-bromobenzylidene)(1-isopropyl-2-methylpropyl)amine (10.71 g) as a clear colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05412102 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-f7fd81c0bba0492f89d5ca0e44113a33 |
| 出典メモ | uspto-grants-1995_05 |