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Methanol → 1-Bromo-4-(dimethoxymethyl)benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 4-Bromobenzaldehyde | HCID 70741 | — |
| 反応物 | Methylorthoformate | HCID 53629101 | — |
| 触媒 | p-Toluenesulfonic acid | HCID 6101 | — |
| 生成物 | 1-Bromo-4-(dimethoxymethyl)benzene | HCID 688342 | — |
反応手順
A mixture of 4-bromobenzaldehyde (21.9 g, 120 mmol), methyl orthoformate (50 mL, 457 mmol), and para-toluenesulfonic acid (0.05 g, 0.29 mmol) in 100 mL of methanol was heated under reflux for 5 hours. The solvent was removed under vacuum and distillation of the remaining residue gave 1-bromo-4-(dimethoxymethyl)benzene (2.24 g, 9.7 mmol) as a clear colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05412102 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-82081e45f2a74ec89216642524d796fa |
| 出典メモ | uspto-grants-1995_05 |