関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Phenylhydrazine | HCID 7516 | — |
| 反応物 | Oxcarbazepine | HCID 34312 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 触媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 10,11-dihydro-10-phenylhydrazono-5H-dibenz[b,f]azepine-5-carboxamide | HCID 57087814 | — |
反応手順
A mixture of 0.2 g (0.8 mmol) of 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide, 0.5 g (4.6 mmol) of phenylhydrazine and 0.5 g (6 mmol) of sodium acetate in a mixture of 5 mL of water, 5 mL of ethanol and 3 drops of concentrated hydrochloric acid was heated at 60° C. for thirty minutes and then allowed to cool to room temperature. The precipitate was then filtered and washed with cold water and dilute ethanol to give the desired product as yellow crystals of m.p. 220° to 220.8° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05866566 |
|---|
| 出典データセット | uspto-grants-1999_02 |
|---|
| ORD ID | ord-855a5c958cf4417daab61cf5df6532a4 |
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| 出典メモ | uspto-grants-1999_02 |
|---|
