5-Aminouracil → 2499-96-9

HRID 361406

反応式

HRID 361406 の反応式
[NH2:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[CH:10](=O)/[CH:11]=[CH:12]/[CH3:13]>Cl>[O:8]=[C:5]1[NH:6][C:7]2[CH:10]=[CH:11][C:12]([CH3:13])=[N:1][C:2]=2[C:3](=[O:9])[NH:4]1

参加物

4

反応物 2

HCID 136115-AminouracilHCID 447466Crotonaldehyde

生成物 1

HCID 2732402499-96-9収率 248.1%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

20 g of 5-aminouracil (40 mmol), 80 ml of 20% HCl and 4 ml of crotonaldehyde (50 mmol) were heated together under reflux for 1 hour. The solution was evaporated to dryness under rotarary evaporation. Water was added to the residue so as to make the mixture just stirrable and then it was triturated with ammonium hydroxide with strong stirring until the pH increased to 10-11. Stirring was continued for another 10 minutes. The precipitate was filtered and was washed with minimal methanol and then chloroform and dried to give 17.58 g (63%) of 1.

後処理

  1. temperatureunder reflux for 1 hour
  2. customThe solution was evaporated to dryness under rotarary evaporation
  3. additionWater was added to the residue so as
  4. customit was triturated with ammonium hydroxide
  5. temperatureincreased to 10-11
  6. stirringStirring
  7. filtrationThe precipitate was filtered
  8. washwas washed with minimal methanol
  9. dry with materialchloroform and dried

出典と根拠

ORDレコード
ord-c564fdbb6d5044b58a8ed55a50be5794
出典データセット
uspto-grants-1999_02
特許番号
US05866580

関連ノート

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