Acetyl chloride → N-heptylacetamide
反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].CCN(CC)CC.[C:16](Cl)(=[O:18])[CH3:17]>C(Cl)Cl>[CH2:2]([NH:1][C:16](=[O:18])[CH3:17])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]参加物
5
実験手順
To a solution of 5.0 gms of 1-aminoheptane in 150 ml of CH2Cl2, is added 10.9 ml of Et3N followed by 2.79 ml of acetyl chloride. The reaction mixture is stirred at room temperature for 18 hours and then concentrated under vacuum. The residue obtained is partitioned between ethyl acetate and an aqueous 2N HCl solution; and after separating, the organic layer is washed with aqueous saturated NaHCO3, then brine, and dried over Na2SO4. After filtration and concentration, N-heptylacetamide is obtained as a clear liquid.
後処理
- concentrationconcentrated under vacuum
- customThe residue obtained
- customis partitioned between ethyl acetate
- customand after separating
- washthe organic layer is washed with aqueous saturated NaHCO3
- dry with materialbrine, and dried over Na2SO4
- filtrationAfter filtration and concentration
出典と根拠
- ORDレコード
- ord-aa92479e490c4c7cb0c1c0157c454a43
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05412137
反応ノート
読み込み中…