Water → N-(10,11-Dihydroxyundecyl)phthalimide

関与物質

役割	名称	HCID	仕込み量
反応物	Water	HCID 962	—
反応物	Sodium Sulfite	HCID 24437	—
反応物	Methyl morpholine oxide	HCID 82029	—
反応物	2-(Undec-10-en-1-yl)-1H-isoindole-1,3(2H)-dione	HCID 22044522	—
溶媒	Propan-2-one--water (1/1)	HCID 18366337	—
生成物	N-(10,11-Dihydroxyundecyl)phthalimide	HCID 12988906	71%

反応手順

A solution of N-(10-Undecenyl)phthalimide (4.97 g, 16.6 mmol), prepared as discribed above, 4-methylmorpholine-N-oxide (8.62 mL, 60% by wt in water, 50.0 mmol) and potassium osmate dihydrate (58 mg, 0.16 mmol) in 100 mL acetone/water (1:1 by wt) was stirred for 16 hours. Water (100 mL) and sodium sulfite (10 g) were added and the resulting solution stirred for an additional hour. The resulting reaction mixture was extracted with dichloromethane (3×80 mL) and the organic phase dried using magnesium sulfate and evaporated to obtain 3.93 g (71% yield) of N-(10,11-Dihydroxyundecyl)phthalimide (inventive compound no. 1108).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US05866576
出典データセット	uspto-grants-1999_02
ORD ID	ord-f72a386d50494ecc856b4636ca1533b3
出典メモ	uspto-grants-1999_02