Hydrochloric Acid → Ethyl valerimidate

HRID 36173

反応式

HRID 36173 の反応式
Cl.[C:2](=[NH:10])([O:7][CH2:8][CH3:9])[CH2:3][CH2:4][CH2:5][CH3:6].C(#N)CCCC.C(O)C.Cl>C(=O)([O-])[O-].[K+].[K+]>[C:2](=[NH:10])([O:7][CH2:8][CH3:9])[CH2:3][CH2:4][CH2:5][CH3:6]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 8061ValeronitrileHCID 12283341Ethyl pentanimidate hydrochloride

生成物 1

HCID 12283340Ethyl valerimidate収率 72%

試薬・触媒・溶媒 1

HCID 11430Potassium Carbonate溶媒

実験手順

A 12.7 g (76.7 mmole) sample of ethyl valerimidate hydrochloride [prepared from valeronitrile, ethanol, and hydrogen chloride gas as described by A. J. Hill and I. Rabinowitz, J. Am. Chem. Soc., 48, 734 (1926)] was dissolved in 33% (w/w) potassium carbonate solution (made by dissolving 15 g of K2CO3 in 30 ml of H2O) and immediately extracted with ether (3×40 ml). The combined ether layers were dried over Na2SO4, filtered, and concentrated in vacuo to give 7.09 g (72%) of the product as a clear oil, which was used directly in the next step.

後処理

  1. extractionimmediately extracted with ether (3×40 ml)
  2. dry with materialThe combined ether layers were dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-4b266a3609384aaf8717b6c4ba7ea463
出典データセット
uspto-grants-1995_05
特許番号
US05411980

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