Tert-butyl 2-(piperidin-4-yl)acetate → N-4-cyanobenzoyl-beta-phenylalpha,alpha-dimethyl-beta-alanyl-4-piperidineacetic acid t-butyl ester

HRID 361760

反応式

HRID 361760 の反応式
[C:1]([C:3]1[CH:24]=[CH:23][C:6]([C:7]([NH:9][CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]([CH3:16])([CH3:15])[C:12](O)=[O:13])=[O:8])=[CH:5][CH:4]=1)#[N:2].[NH:25]1[CH2:30][CH2:29][CH:28]([CH2:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH2:27][CH2:26]1>>[C:35]([O:34][C:32](=[O:33])[CH2:31][CH:28]1[CH2:29][CH2:30][N:25]([C:12](=[O:13])[C:11]([CH3:15])([CH3:16])[CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:9][C:7](=[O:8])[C:6]2[CH:23]=[CH:24][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:26][CH2:27]1)([CH3:38])([CH3:37])[CH3:36]

参加物

3

反応物 2

HCID 23511620Tert-butyl 2-(piperidin-4-yl)acetateHCID 70199446N-4-cyanobenzoyl-beta-phenyl-alpha,alpha-dimethyl-beta-alanine

生成物 1

HCID 86753674N-4-cyanobenzoyl-beta-phenylalpha,alpha-dimethyl-beta-alanyl-4-piperidineacetic acid t-butyl ester収率 60.2%

実験手順

The same procedure as in Example 2-(6-2) was performed with N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanine (0.5 g, 1.55 mmol) using t-butyl 4-piperidine acetate (0.93 g, 4.66 mmol) to yield an oil of N-4-cyanobenzoyl-β-phenylα,α-dimethyl-β-alanyl-4-piperidineacetic acid t-butyl ester (470 mg, 60.2%).

出典と根拠

ORDレコード
ord-ab51de6bcaf24e48b5e2c098cb0fe601
出典データセット
uspto-grants-1999_02
特許番号
US05866592

関連ノート

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