3-Cyclohexyl-L-alanine → Methyl 3-cyclohexyl-L-alaninate
反応式
N1CCC(CCCC(N(CC)CC(N[C@H](C([NH:24][C@H:25]([C:33]([OH:35])=[O:34])[CH2:26][CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)=O)CC(=O)O)=O)=O)CC1.[CH:38]1(C[C@@H](C(O)=O)N)CCCCC1>CO.Cl>[CH3:38][O:35][C:33](=[O:34])[C@H:25]([CH2:26][CH:27]1[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]1)[NH2:24]参加物
5
実験手順
N-[N-[N-(4-(piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-β-cyclohexylalanine ##STR6##A. β-cyclohexylalanine (1.12 g) is dissolved in of methanol (50 ml) and hydrogen chloride gas is bubbled through the solution for about 15 minutes. The solution is evaporated in vacuo and toluene azeotroped from the residue to give β-cyclohexyl-L-alanine methyl ester as the hydrochloride salt.
後処理
- customis bubbled through the solution for about 15 minutes
- customThe solution is evaporated in vacuo and toluene
- customazeotroped from the residue
出典と根拠
- ORDレコード
- ord-e417ce7af4614a46b0fa417b1b4b4153
- 出典データセット
- uspto-grants-1999_02
- 特許番号
- US05866685
反応ノート
読み込み中…