Acetic Acid → N-BOC-2-cyclohexylethylamine
反応式
[C:1]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].C(O)(=O)C>CO.[Rh]>[C:1]([NH:8][CH2:9][CH2:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1)([O:3][C:4]([CH3:6])([CH3:7])[CH3:5])=[O:2]参加物
5
実験手順
N-BOC-2-phenylethylamine (3.1 g) and 5% rhodium on alumina (1.1 g) are combined in methanol (40 ml) containing acetic acid (1.0 ml). The mixture is shaken under hydrogen at 50 psi for about 20 hours. The mixture is filtered, evaporated in vacuo, and the residue taken up into ethyl acetate. The organic solution is washed with water, 5% sodium bicarbonate solution, water, brine, dried over sodium sulfate, filtered, and evaporated in vacuo to give N-BOC-2-cyclohexylethylamine.
後処理
- filtrationThe mixture is filtered
- customevaporated in vacuo
- washThe organic solution is washed with water, 5% sodium bicarbonate solution, water, brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-f4f26d5199f64b5f81b5bb2af41ca5ec
- 出典データセット
- uspto-grants-1999_02
- 特許番号
- US05866685
反応ノート
読み込み中…