Ammonium Chloride → 2,4-Dichlorobenzonitrile

HRID 361947

反応式

HRID 361947 の反応式
[Cl-].[NH4+:2].[Cl:3][C:4]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:5]=1[C:6](Cl)=O>>[Cl:3][C:4]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:5]=1[C:6]#[N:2]

参加物

3

反応物 2

HCID 25517Ammonium ChlorideHCID 666452,4-Dichlorobenzoyl chloride

生成物 1

HCID 810502,4-Dichlorobenzonitrile収率 699.5%

反応条件

温度
230 °C

実験手順

The reaction was performed as in Example 1. The following reactants were charged to the reactor: 2,4-DCBTC (132.8 g, 0.5 mol), ammonium chloride (28.1 g, 1.05 eq), and 2,4-dichlorobenzoyl chloride (13.3 g). The mixture was heated at 230° C. for 14 h. Distillation of the reaction mixture gave pure 2,4-dichlorobenzonitrile (2,4-DCBN) (76.4 g, 89% yield, melting point: 59°-60° C.).

後処理

  1. additionThe following reactants were charged to the reactor
  2. distillationDistillation of the reaction mixture

出典と根拠

ORDレコード
ord-4d30bbf7fc0f4dae8d896806608cfed9
出典データセット
uspto-grants-1999_02
特許番号
US05866709

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