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Ethanol → 3-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide dihydrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Ethylenethiourea | HCID 2723650 | — |
| 反応物 | 1-(1-Benzothiophen-3-yl)-2-bromoethan-1-one | HCID 2776341 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide dihydrate | HCID 68779021 | — |
反応手順
A mixture of 3-(2-bromoacetyl)benzo[b]thiophen (2.39 g), 2-imidazolidinethione (0.78 g), ethanol (60 ml) and acetic acid (40 ml) was heated under reflux for 18 hours then allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ether (2×50 ml), and dried in vacuo at ambient temperature to give 3-(benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1 -b]thiazole monohydrobromide dihydrate as a white solid (2.96 g), m.p. 239°-240° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05869492 |
| 出典データセット | uspto-grants-1999_02 |
| ORD ID | ord-fd09965459ef41efa16387e585faa295 |
| 出典メモ | uspto-grants-1999_02 |