Ethanol → 3-(Benzo[b]furan-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide monohydrate

HRID 362258

反応式

HRID 362258 の反応式
[Br:1][CH2:2][C:3]([C:5]1[C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[O:8][CH:9]=1)=[O:4].[NH:14]1[CH2:18][CH2:17][NH:16][C:15]1=[S:19].C(O)C>C(O)(=O)C>[OH2:4].[BrH:1].[O:8]1[CH:9]=[C:5]([C:3]2[N:16]3[CH2:17][CH2:18][N:14]=[C:15]3[S:19][CH:2]=2)[C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]1=2

参加物

5

反応物 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 27765801-(Benzofuran-3-yl)-2-bromoethanone

生成物 1

HCID 702862843-(Benzo[b]furan-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide monohydrate収率 40.6%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 3-(2-bromoacetyl)benzo[b]furan (0.25 g), 2-imidazolidinethione (0.11 g), ethanol (30 ml) and acetic acid (20 ml) was heated under reflux for 20 hours, then allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ether, and dried in vacuo at ambient temperature to give 3-(benzo[b]furan-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide monohydrate as a white solid (0.145 g), m.p. 242°-244° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 20 hours
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with ether
  5. customdried in vacuo at ambient temperature

出典と根拠

ORDレコード
ord-5ea882d0114b46a19725bfebd4a0ef53
出典データセット
uspto-grants-1999_02
特許番号
US05869492

関連ノート

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