Ethanol → HCID 70284500、化合物

HRID 362266ノート

反応式

HRID 362266 の反応式
[Br:1][CH2:2][C:3]([C:5]1[C:6]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:7]=2[S:8][CH:9]=1)=O.[NH:15]1[CH2:19][CH2:18][NH:17][C:16]1=[S:20].C(O)C>C(O)(=O)C>[BrH:1].[Cl:14][C:12]1[CH:11]=[CH:10][C:7]2[S:8][CH:9]=[C:5]([C:3]3[N:17]4[CH2:18][CH2:19][N:15]=[C:16]4[S:20][CH:2]=3)[C:6]=2[CH:13]=1

参加物

5

反応物 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 57175247HCID 57175247、化合物

生成物 1

HCID 70284500HCID 70284500、化合物収率 57.4%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of the crude 3-(2-bromoacetyl)-5-chlorobenzo[b]thiophen (4.2 g), 2-imidazolidinethione (1 g), ethanol (15 ml) and acetic acid (10 ml) was heated under reflux under nitrogen for 18 hours, then allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ethanol (15 ml), and dried in vacuo to give 3-(5-chlorobenzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide as a white solid (2.1 g), m.p. 286°-288° C. (dec.).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux under nitrogen for 18 hours
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with ethanol (15 ml)
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-018a43fac15a4943bd2445c6946d8fdc
出典データセット
uspto-grants-1999_02
特許番号
US05869492

反応ノート

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