Chlorine → 2-Chloro-5H-dibenzo[b,e]azepine-6,11-dione
反応式
[CH:1]1[C:11]2[C:10](=[O:12])[C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[C:7](=[O:17])[NH:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[Cl:18]Cl>C(O)(=O)C>[Cl:18][C:2]1[CH:3]=[CH:4][C:5]2[NH:6][C:7](=[O:17])[C:8]3[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=3[C:10](=[O:12])[C:11]=2[CH:1]=1参加物
4
反応条件
- 温度
- 38 °C
実験手順
A mixture of 1.0 g of 5H-dibenz[b,e]azepine-6,11-dione in 50 ml of acetic acid is stirred while chlorine is bubbled into the reaction mixture until saturated. The temperature increases to 38° C. After standing, a precipitate forms and is filtered, washed with hexane and air dried to give 0.62 g of solid which is purified by chromatography to give the desired product as a solid, m.p. 289°-293° C.
後処理
- customis bubbled into the reaction mixture until saturated
- filtrationa precipitate forms and is filtered
- washwashed with hexane and air
- customdried
出典と根拠
- ORDレコード
- ord-5e7729c866d34afaa2bc0a06d3e96afa
- 出典データセット
- uspto-grants-1999_02
- 特許番号
- US05869483
反応ノート
読み込み中…