Hydrochloric Acid → 1,3-Dibenzylpiperidin-4-one
反応式
C([C:5]1([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:10](=[O:11])[CH2:9][CH2:8][N:7]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:6]1)(OC)=O.Cl>CO>[CH2:12]([N:7]1[CH2:8][CH2:9][C:10](=[O:11])[CH:5]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:6]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1参加物
4
実験手順
A solution of 3-carbomethoxy-1,3-dibenzyl-4-piperidone (0.61 g, 1.78 mmol), MeOH (10 mL) and 5M HCl aq. (25 mL, 125 mmol) was refluxed overnight. The reaction mixture was concentrated and chromatographed (silica gel, eluting with 4:1 hexane-EtOAc) to give 1,3-dibenzyl-4-piperidone (0.31 g).
後処理
- concentrationThe reaction mixture was concentrated
- customchromatographed
- wash(silica gel, eluting with 4:1 hexane-EtOAc)
出典と根拠
- ORDレコード
- ord-f145b1af83a546b4a75ea44357d436b1
- 出典データセット
- uspto-grants-1999_02
- 特許番号
- US05869488
反応ノート
読み込み中…