Sulfuryl chloride → 3-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

HRID 362653ノート

反応式

HRID 362653 の反応式
[F:1][CH:2]([F:14])[O:3][C:4]1[N:8]([CH3:9])[N:7]=[C:6]([C:10]([O:12][CH3:13])=[O:11])[CH:5]=1.S(Cl)([Cl:18])(=O)=O>C(Cl)Cl>[Cl:18][C:5]1[C:6]([C:10]([O:12][CH3:13])=[O:11])=[N:7][N:8]([CH3:9])[C:4]=1[O:3][CH:2]([F:1])[F:14]

参加物

4

反応物 2

HCID 24648Sulfuryl chlorideHCID 54319416Methyl 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxylate

生成物 1

HCID 537351233-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2.1 g (10 mmol) 5-Difluoromethoxy-3-methoxycarbonyl-1-methylpyrazole, dissolved in 30 ml methylene chloride, was treated with 1.35 g (10 mmol) sulfuryl chloride and the mixture stirred at room temperature for 10 minutes. It was then concentrated and the residue recrystallised from diisopropyl ether/ethyl acetate.

後処理

  1. concentrationIt was then concentrated
  2. customthe residue recrystallised from diisopropyl ether/ethyl acetate

出典と根拠

ORDレコード
ord-0730b82069b94c9d8e03c745348d8f04
出典データセット
uspto-grants-1999_02
特許番号
US05869686

反応ノート

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