2-(Ethoxymethylene)propanedinitrile → 5-Amino-4-cyano-1-(1-methyl-5-methylmercapto-3-pyrazolyl)pyrazole
反応式
[NH:1]([C:3]1[CH:7]=[C:6]([S:8][CH3:9])[N:5]([CH3:10])[N:4]=1)[NH2:2].C(O[CH:14]=[C:15]([C:18]#[N:19])[C:16]#[N:17])C>C(O)C>[NH2:19][C:18]1[N:1]([C:3]2[CH:7]=[C:6]([S:8][CH3:9])[N:5]([CH3:10])[N:4]=2)[N:2]=[CH:14][C:15]=1[C:16]#[N:17]参加物
4
実験手順
A mixture of 2.0 g (13.1 mmol) 3-Hydrazino-1-methyl-5-methylmercaptopyrazole and 1.8 g (14.4 mmol) ethoxymethylenemalononitrile in 25 ml ethanol was stirred for 30 minutes at room temperature and heated at boiling point for 3 hours. The reaction mixture was concentrated and the residue purified by silica gel chromatography (hexane/ethyl acetate 1:1).
後処理
- temperatureheated
- customfor 3 hours
- concentrationThe reaction mixture was concentrated
- customthe residue purified by silica gel chromatography (hexane/ethyl acetate 1:1)
出典と根拠
- ORDレコード
- ord-fc187a79c35a4458892cf710dabf2658
- 出典データセット
- uspto-grants-1999_02
- 特許番号
- US05869686
反応ノート
読み込み中…