化工社化工社 化学情報印刷レポート · 研究参考用
Thionyl Chloride → 3-(4-Fluorophenyl)propionyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 3-(4-Fluorophenyl)propionic acid | HCID 136302 | — |
| 生成物 | 3-(4-Fluorophenyl)propionyl chloride | HCID 21964258 | 96.3% |
反応手順
A mixture of 3-(4-fluorophenyl)propionic acid (275.1 g, 1.6 mol) and thionyl chloride (300 mL, 4.1 mol) was heated to reflux for 3 h, cooled to room temperature and distilled under aspirator vacuum to give 287.6 g (96%) of 3-(4-fluorophenyl)propionyl chloride as a pale pink oil, b.p., 120°-122° C./15 mm Hg:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05872118 |
| 出典データセット | uspto-grants-1999_02 |
| ORD ID | ord-b35a9893a28d48c2b269c358caf2e0f2 |
| 出典メモ | uspto-grants-1999_02 |