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Dichloromethane → 5-n-Butyl-2-[2-chloro-5-(methoxycarbonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Methyl 4-chloro-3-hydrazinylbenzoate | HCID 292358 | — |
| 反応物 | ethyl N-carbethoxyvalerimidate | HCID 53930077 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-n-Butyl-2-[2-chloro-5-(methoxycarbonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 135720082 | 37% |
反応手順
By the procedure of Example 4, Step C, the title compound was prepared from methyl 4-chloro-3-hydrazinobenzoate (from Step B) and ethyl N-carbethoxyvalerimidate (from Example 4, Step B) in 37% yield as an orange gum (TLC in 95:5 CH2Cl2 --MeOH), mass spectrum (FAB) m/e 310 (M+1)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05411980 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-f823704f88f141b384feb5badfe9a1a0 |
| 出典メモ | uspto-grants-1995_05 |