2-(4,6-Difluoro-1-hydroxy-1-indanyl)acetic acid → (E)-2-(5-fluoro-1-indanylidene)acetic acid

反応式

F[C:2]1[CH:10]=[C:9](F)[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5]/[C:6]/2=[CH:12]\[C:13]([OH:15])=[O:14].[F:16]C1C=C(F)C=C2C=1CCC2(CC(O)=O)O>>[F:16][C:10]1[CH:2]=[C:3]2[C:7](=[CH:8][CH:9]=1)/[C:6](=[CH:12]/[C:13]([OH:15])=[O:14])/[CH2:5][CH2:4]2

参加物

反応物 2

HCID 109112982-(4,6-Difluoro-1-hydroxy-1-indanyl)acetic acid

HCID 10976722(E)-2-(4,6-difluoro-1-indanylidene)acetic acid

生成物 1

HCID 23293571(E)-2-(5-fluoro-1-indanylidene)acetic acid収率 68%

実験手順

This compound was prepared in an analogous manner to (E)-2-(4,6difluoro-1-indanylidene)acetic acid in Example 5e by substituting 2-(5-fluoro-1-hydroxy-1-indanyl)acetic acid(14.70 g, 0.069 mol) for 2-(4,6-difluoro-1-hydroxy-1-indanyl)acetic acid. Recrystallization from acetonitrile: 2-propanol mixtures gave 9.05 g (68%) of (E)-2-(5-fluoro-1-indanylidene)acetic acid as a white solid: m.p., 240°-242° C.;

後処理

customRecrystallization from acetonitrile

出典と根拠

ORDレコード: ord-0d51c22016904a09a6d658476ba1f206
出典データセット: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05872118

反応ノート

読み込み中…

参加物