(E)-2-(6-fluoro-1-indanylidene)acetamide → (E)-2-(5-fluoro-1-indanylidene)acetamide
反応式
F[C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7]/[C:8]/2=[CH:11]\[C:12]([NH2:14])=[O:13])=[CH:4][CH:3]=1.[F:15]C1C=C2C(CC/C/2=C\C(Cl)=O)=CC=1>>[F:15][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:2]=1)/[C:8](=[CH:11]/[C:12]([NH2:14])=[O:13])/[CH2:7][CH2:6]2参加物
3
実験手順
This compound was prepared in a similar manner to that described for (E)-2-(6-fluoro-1-indanylidene)acetamide Example 1k by substituting (E)-2-(5-fluoro-1-indanylidene)acetyl chloride (3.16 g, 0.015 mol) for (E)-2-(6-fluoro-1-indanylidene)acetyl chloride. Recrystallization from acetonitrile: water mixtures gave 1.28 g (44%) of (E)-2-(5-fluoro-1-indanylidene)acetamide as a white solid; m.p., 191°-193° C.;
後処理
- customThis compound was prepared in a similar manner to that
- customRecrystallization from acetonitrile
出典と根拠
- ORDレコード
- ord-061ec2a7f1ec41f2874d7ba6bf4b98b2
- 出典データセット
- uspto-grants-1999_02
- 特許番号
- US05872118
反応ノート
読み込み中…