化工社化工社 化学情報印刷レポート · 研究参考用
4-Bromo-2-fluorotoluene → 3-Fluoro-4-methyl-2'-(N-t-butylsulfamoyl)biphenyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromo-2-fluorotoluene | HCID 171040 | — |
| 反応物 | Boronic acid, B-(2-(((1,1-dimethylethyl)amino)sulfonyl)phenyl)- | HCID 4997616 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | 3-Fluoro-4-methyl-2'-(N-t-butylsulfamoyl)biphenyl | HCID 10087424 | 92% |
反応手順
The palladium(0)-catalyzed coupling of 4-bromo-2-fluorotoluene with 2-(N-t-butylsulfamoyl)phenylboronic acid was carried out according to the procedure of Example 76, Step F. Purification of the crude product by flash chromatography (elution with hexane-EtOAc) gave a 92% yield of the title compound as an off-white foam (TLC in 4:1 hexane-EtOAc); mass spectrum (FAB) m/e 322 (M+1)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05411980 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-3d6b6f4d22314c4ab5ae4e244b8af097 |
| 出典メモ | uspto-grants-1995_05 |