反応式
[C:1]([O:6]C)(=O)[C:2]#[C:3][CH3:4].[CH2:8]([Mg]Br)[CH3:9].[Cl-].[NH4+].[CH3:14][CH2:15]OCC>>[CH2:14]([C:1]([OH:6])([CH2:8][CH3:9])[C:2]#[C:3][CH3:4])[CH3:15]参加物
5
実験手順
A solution of methyl 2-butynoate (1.5 g) in ether (50 ml) was cooled to 0°, treated with ethyl magnesium bromide (21 ml of a 3M solution in ether) and stirred at room temperature for 4 hours. The mixture was then cooled to 0° and treated with saturated ammonium chloride solution, whereafter the product was extracted into ether and the title compound (1.2 g) was isolated by chromatography. IR (CCl4) νmax 2200 (C≡C), 3450 cm-1 (OH); NMR (CCl4) δ 1.83 (s, H3C--C≡), 2.3 (s), 1.36-1.6 (m, CH2CH3), 0.93 (t, CH3CH2).
後処理
- temperatureThe mixture was then cooled to 0°
- extractionwas extracted into ether
出典と根拠
- ORDレコード
- ord-f9ef5d397b054e2b896dbc3f21cf77d0
- 出典データセット
- uspto-grants-1999_02
- 特許番号
- US05872140
関連ノート
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