Methyl 4-(allyloxy)benzoate → Methyl 3-allyl-4-hydroxybenzoate

HRID 363037ノート

反応式

HRID 363037 の反応式
C([O:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)C=C.CCOC(C)=O.[CH3:21][CH2:22][CH2:23]CCC>>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:13][C:14]=1[CH2:23][CH:22]=[CH2:21]

参加物

3

反応物 2

HCID 4645407Methyl 4-(allyloxy)benzoateHCID 21226206Ethyl acetate hexane

生成物 1

HCID 939882Methyl 3-allyl-4-hydroxybenzoate

実験手順

The neat allyl ether 22-2 from Step A (7.0 g, 38.6 mmol) was heated in an oil bath at 230 ° C. for 1 h. The reaction was followed by NMR and was found to be complete after 90 min. The resulting brown oil was cooled and subjected to column chromatography (1:1 EtOAc/Hexane) to afford 22-3 as a white solid.

後処理

  1. temperatureThe resulting brown oil was cooled

出典と根拠

ORDレコード
ord-761d500b91984ea28cfab57deeae24f5
出典データセット
uspto-grants-1999_02
特許番号
US05872138

反応ノート

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