4-(3-Fluorophenyl)-3-buten-1-ol → 3-Fluoro-benzenebutanol

HRID 363081ノート

反応式

HRID 363081 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH2:10][CH2:11][OH:12])[CH:5]=[CH:6][CH:7]=1.[H][H]>[C].[Pd].C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][CH2:11][OH:12])[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 536388864-(3-Fluorophenyl)-3-buten-1-olHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 540408183-Fluoro-benzenebutanol収率 89.5%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

In a reaction vessel were placed 0.53 g of 4-(3-fluorophenyl)-3-buten-1-ol and 50 ml of ethyl acetate, and the air in the vessel was exchanged for nitrogen. Then, 0.1 g of 10% palladium carbon was added thereto, and the nitrogen in the vessel was exchanged for hydrogen, followed by vigorous stirring at room temperature for 24 hours. After the hydrogen in the vessel was exchanged for nitrogen, the reaction solution was filtered through a celite bed, and the filtrate was concentrated. The residue was subjected to silica gel chromatography, which afforded 0.48 g of 4-(3-fluorophenyl)-1-butanol.

後処理

  1. customIn a reaction vessel were placed
  2. filtrationthe reaction solution was filtered through a celite bed
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-329321572bed4df2bf1df618f2db5072
出典データセット
uspto-grants-1999_02
特許番号
US05872137

反応ノート

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