Benzyl Bromide → 4-Bromo-6-chloro-2-methyl-1-benzyloxybenzene

HRID 363104ノート

反応式

HRID 363104 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([OH:9])=[C:4]([CH3:10])[CH:3]=1.[CH2:11](Br)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:4]([CH3:10])[CH:3]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 820314-Bromo-6-chloro-o-cresol

生成物 1

HCID 185046304-Bromo-6-chloro-2-methyl-1-benzyloxybenzene収率 90%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 50 g of 4-bromo-6-chloro-2-methylphenol and 42.5 g of benzyl bromide dissolved in 200 ml of N,N-dimethylformamide was stirred at room temperature, to which 37.4 g of potassium carbonate was added, and the mixture was stirred for 12 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure, and the residue was added to 400 ml of diethyl ether, washed with water, dried with anhydrous magnesium sulfate, and concentrated to obtain a crude product. The crude product was subjected to silica gel chromatography, which afforded 63 g of 4-bromo-6-chloro-2-methyl-1-benzyloxybenzene (90% yield).

後処理

  1. additionwas added
  2. customAfter completion of the reaction
  3. customthe solvent was removed by distillation under reduced pressure
  4. additionthe residue was added to 400 ml of diethyl ether
  5. washwashed with water
  6. dry with materialdried with anhydrous magnesium sulfate
  7. concentrationconcentrated
  8. customto obtain a crude product

出典と根拠

ORDレコード
ord-b2c7d625e14b45bf9a8c41ad2155fec3
出典データセット
uspto-grants-1999_02
特許番号
US05872137

反応ノート

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