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Anthranilic Acid → 2-(Octanoylamino)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Anthranilic Acid | HCID 227 | — |
| 反応物 | Chloride | HCID 312 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(Octanoylamino)benzoic acid | HCID 4157220 | 79.4% |
反応手順
Anthranilic acid was dissolved in a mixed solvent containing pyridine and tetrahydrofuran (THF) in 5:5 ratio and a THF solution of n-caprioyl chloride was dropped to the solution during several hours for reaction. After the reaction, hydrochloric acid was added to the reaction mixture. Pyridine hydrochloride was filtered and the solvent was removed. N-n-octanoylanthranilic acid was obtained from the remaining reactant after the purification by column chromatography with the yield of 79.4%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05413794 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-26de8cb6b8ab4be3a4b1393e37538166 |
| 出典メモ | uspto-grants-1995_05 |