4-Methoxybenzenesulfonamide → N-[4-(2-bromoethyl)benzoyl]-4-methoxybenzenesulfonamide

関与物質

反応手順

A mixture of 18.72 g (0.10 mol) of 4-methoxybenzenesulfonamide, 24.75 g (0.10 mol) of 4-(2-bromoethyl)benzoyl chloride and 200 ml of toluene was stirred and heated to reflux at which time solution was achieved. The solution was heated at reflux for 16.5 hrs. The vapors emitted from the condenser were acidic during reaction. After this time, the solution was cooled and concentrated to an oil. The oil was dissolved in 3:7 heptane:toluene and cooled. Solid crystallized and was collected, washed with ligroine and dried.

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