Dimethylformamide dimethyl acetal → 2-(6-Chloro-3-nitropyridin-2-yl)-N,N-dimethylethen-1-amine

HRID 363323ノート

反応式

HRID 363323 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][CH:3]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CN(C)C=O.C(N(CC)CC)C>[CH3:14][N:15]([CH3:17])[CH:16]=[CH:8][C:6]1[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][CH:3]=[C:2]([Cl:1])[N:7]=1

参加物

5

反応物 2

HCID 78373Dimethylformamide dimethyl acetal2 回HCID 2531236-Chloro-2-methyl-3-nitropyridine

生成物 1

HCID 537327152-(6-Chloro-3-nitropyridin-2-yl)-N,N-dimethylethen-1-amine

試薬・触媒・溶媒 2

HCID 8471Triethylamine触媒HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

A solution of 5 gm (29 mMol) 6-chloro-3-nitro-2-picoline in 40 mL dimethylformamide was treated with 5.83 mL (44 mMol) dimethylformamide dimethylacetal and the resulting mixture heated at 100° C. for 1.5 hours. At this point, 2 drops of triethylamine followed by 1.9 mL dimethylformamide dimethylacetal were added and heating continued for 2 more hours. The reaction mixture was concentrated under reduced pressure to provide the desired compound.

後処理

  1. additionwere added
  2. temperatureheating
  3. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-c41032bbabc94757a6fef27dc577d9cd
出典データセット
uspto-grants-1999_02
特許番号
US05874427

反応ノート

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