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Triethylamine → N-(2(R)-hydroxy-1(S)-indanyl)-3-phenylpropaneamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzenepropanoyl chloride | HCID 64801 | — |
| 反応物 | (1S,2R)-(-)-1-Amino-2-indanol | HCID 9866743 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(2(R)-hydroxy-1(S)-indanyl)-3-phenylpropaneamide | HCID 22857039 | — |
反応手順
To a cold (0° C.) solution of methylene chloride (30 ml) containing 2(R)-hydroxy-1(S)-aminoindane (750 mg, 5.0 mmol) and triethylamine (606 mg, 6.0 mmol) was added a solution of hydrocinnamoyl chloride (843 mg, 5.0 mmol) in 5 ml of methylene chloride. After 2 hr the reaction was poured into a separatory funnel containing 50 ml of methylene chloride and washed with 10% citric acid solution (2×30 ml). The organic layer was dried, filtered and concentrated to afford a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05413999 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-c6b393091b0d4e87a9a90ad1c747c4d7 |
| 出典メモ | uspto-grants-1995_05 |