Diethyl Ether → HCID 135537121、化合物

HRID 363361ノート

反応式

HRID 363361 の反応式
Cl[C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[CH2:19]([NH2:21])[CH3:20].C(OCC)C>C(O)C>[CH2:19]([NH:21][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[NH:5][C:6](=[O:8])[CH:7]=1)[CH3:20]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 6341EthylamineHCID 178458304HCID 178458304、化合物

生成物 1

HCID 135537121HCID 135537121、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-Chloro-6-hydroxy-2-(2-propoxyphenyl)-pyrimidine (0.66 g) and ethylamine in ethanol (33%, 20 ml) was heated at 90° C. in a pressure vessel for 16 hours. The cooled reaction mixture was evaporated under reduced pressure to yield an oil which solidified on trituration with diethyl ether. The residue was recrystallized from isopropanol:diethyl ether, washed with water and recrystallized from isopropanol:water to yield the title compound, 0.47 g, m.p. 187°-80° C.

後処理

  1. customThe cooled reaction mixture
  2. customwas evaporated under reduced pressure
  3. customto yield an oil which
  4. customThe residue was recrystallized from isopropanol
  5. washdiethyl ether, washed with water
  6. customrecrystallized from isopropanol

出典と根拠

ORDレコード
ord-4f5a7f92a2b84c1b8402292506249c9e
出典データセット
uspto-grants-1999_02
特許番号
US05874440

反応ノート

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