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Phosphorus tribromide → 3-Methoxybenzyl bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus tribromide | HCID 24614 | — |
| 反応物 | 3-Methoxybenzyl alcohol | HCID 81437 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-Methoxybenzyl bromide | HCID 4067207 | — |
反応手順
A solution of 270 ul of 3-methoxybenzyl alcohol in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul PBr3 added, followed by stirring for three hours. The reaction mixture is extracted with ether and the organic layer washed with saturated sodium bicarbonate and evaporated to give the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05414001 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-d0021b55fed847d8be332381521d5721 |
| 出典メモ | uspto-grants-1995_05 |