化工社化工社 化学情報印刷レポート · 研究参考用
3-Bromobenzoic acid → 1-Bromo-3-tert-butylbenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Bromobenzoic acid | HCID 11456 | — |
| 反応物 | 1-(tert-Butyl)-3-ethynylbenzene | HCID 14989667 | — |
| 反応物 | Trimethylaluminum | HCID 16682925 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 1-Bromo-3-tert-butylbenzene | HCID 343798 | — |
反応手順
Reaction Scheme 4 discloses a specific synthetic route to 3-tert-butylphenyl ethyne (Compound 22) starting with meta bromobenzoic acid (Compound 23), which is treated with trimethylaluminum in hexane to yield 3-tert-butyl bromobenzene (Compound 24). 3-Tert-butyl bromobenzene 24 is thereafter converted into the ethyne derivative 22 through the trimethylsilyl ethyne intermediate 25 in steps similar to the steps described in connection with Reaction Scheme 3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05414007 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-1545945aa4924efca8fa5810dddf53f3 |
| 出典メモ | uspto-grants-1995_05 |