Water → Ethyl 2-(1,3-dioxoisoindolin-2-yl)-2-fluoroacetate
反応式
Br[CH:2]([F:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[C:9]1([C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][O:11]1)=[O:10].[K].CCOCC.O.C[N:27](C)C=O>>[O:10]=[C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12](=[O:11])[N:27]1[CH:2]([F:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4]参加物
6
反応条件
- 温度
- 80 °C
実験手順
A stirred mixture of ethyl bromofluoroacetate (1.0 g, 5.4 mmol) and potassium phthalide (1.0 g, 5.4 mmol) in dimethylformamide (10 mL) is heated at 80° C. for 3 hours. The mixture is stirred with ether (50 mL) and water (50 mL) and the organic layer then washed with water and brine (30 mL each), and dried over sodium sulfate. The solvent is removed in vacuo to give ethyl 2-(1,3-dioxoisoindolin-2-yl)-2-fluoroacetate which is further purified through chromatography.
後処理
- washthe organic layer then washed with water and brine (30 mL each)
- dry with materialdried over sodium sulfate
- customThe solvent is removed in vacuo
出典と根拠
- ORDレコード
- ord-adc2f0d352cc4ef2ad1036de8b178de2
- 出典データセット
- uspto-grants-1999_02
- 特許番号
- US05874448
反応ノート
読み込み中…