Hydrochloric Acid → 2-(5-Chloro-2-nitrophenoxy)-5-methoxybenzoic acid

HRID 364175ノート

反応式

HRID 364175 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:21]([O-:23])=[O:22])=[C:6]([CH:20]=1)[O:7][C:8]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:9]=1[C:10]([O:12]C)=[O:11].[OH-].[K+].Cl>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:21]([O-:23])=[O:22])=[C:6]([CH:20]=1)[O:7][C:8]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:9]=1[C:10]([OH:12])=[O:11]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 136890962-(5-Chloro-2-nitrophenoxy)-5-methoxybenzoic acid, methyl ester

生成物 1

HCID 136890952-(5-Chloro-2-nitrophenoxy)-5-methoxybenzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a stirred suspension of 65 g of 2-(5-chloro-2-nitrophenoxy)-5-methoxybenzoic acid, methyl ester, in 600 ml of methanol, was added 97.5 ml of 6M KOH solution. This suspension was stirred for 18 hours and the solution which resulted was neutralized with 200 ml of 10% HCl solution. The precipitated crude acid product was collected by filtration and, after recrystallization from acetonitrile, yielded the title compound, mp 232°-234° C.

後処理

  1. customthe solution which resulted
  2. customThe precipitated crude acid product
  3. filtrationwas collected by filtration
  4. customafter recrystallization from acetonitrile

出典と根拠

ORDレコード
ord-274139536c184ed5bdb934812ae3ee22
出典データセット
uspto-grants-1986_08
特許番号
US04604390

反応ノート

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