Methanol → 1-chloro-7-hydroxy-4-nitro-9H-xanthen-9-one

HRID 364178ノート

反応式

HRID 364178 の反応式
[Cl:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([O:17]C)[CH:12]=3)[O:7][C:6]=2[C:5]([N+:19]([O-:21])=[O:20])=[CH:4][CH:3]=1.B(Br)(Br)Br.CO>ClCCl>[Cl:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([OH:17])[CH:12]=3)[O:7][C:6]=2[C:5]([N+:19]([O-:21])=[O:20])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 887MethanolHCID 25134Boron tribromideHCID 136890881-Chloro-7-methoxy-4-nitro-9H-xanthen-9-one

生成物 1

HCID 136890891-chloro-7-hydroxy-4-nitro-9H-xanthen-9-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A mixture of 10 g of 1-chloro-7-methoxy-4-nitro-9H-xanthen-9-one and 84 ml of a 1M solution of boron tribromide in dichloromethane in 280 ml of dichloromethane was stirred at room temperature under an argon atmosphere for 16 hours, and then it was treated with 100 ml of methanol, and stirred for three hours. The mixture was filtered to give a light green solid. Recrystallization from chloroformmethanol afforded the title compound, mp 290°-292° C.

後処理

  1. stirringstirred for three hours
  2. filtrationThe mixture was filtered
  3. customto give a light green solid
  4. customRecrystallization from chloroformmethanol

出典と根拠

ORDレコード
ord-81c0d83bec0548e69712b630f7769f82
出典データセット
uspto-grants-1986_08
特許番号
US04604390

反応ノート

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