化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 6-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione | HCID 73273 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 6-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione | HCID 312953 | — |
反応手順
A mixture of 100 g (0.623 mole) of 6-chloromethylpyrimidine-2,4-dione and 200 ml of anhydrous ammonia was allowed to react overnight in a sealed bomb at about 20° C. The solid residue was slurried in ethyl acetate, and was then separated by filtration and washed sequentially with water and methanol to provide 6-aminomethylpyrimidine-2,4-dione, m.p. 295°-297° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04604466 |
| 出典データセット | uspto-grants-1986_08 |
| ORD ID | ord-d7456574a0df47a9baefb0d5625c77d9 |
| 出典メモ | uspto-grants-1986_08 |