関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methyl isocyanide | HCID 11646 | — |
| 反応物 | 2-Methylbenzoyl chloride | HCID 70276 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-methyl-2-(2-methylphenyl)-2-oxoacetamide | HCID 15239356 | — |
反応手順
Methyl isocyanide (0.84 ml) was added to 2-methylbenzoyl chloride (1.55 g). The mixture was stirred at 60° C. for 16 hours. Then, 5N hydrochloric acid (1.5 ml) and acetone (2 ml) were added, and the mixture was stirred at room temperature for 1.5 hours for hydrolysis. Then, water was added. The mixture was extracted with methylene chloride, washed with water and dried. The solvent was evaporated under reduced pressure to obtain the title compound as an oil (1.68 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05414122 |
|---|
| 出典データセット | uspto-grants-1995_05 |
|---|
| ORD ID | ord-33cb00ace74546bf936022e8d0659d2b |
|---|
| 出典メモ | uspto-grants-1995_05 |
|---|
