Ethyl (2Z)-2-methoxyimino-3-oxo-butanoate → Ethyl 2-methoxyimino-3-t-butoxycarbonylhydrazonobutyrate

HRID 364448ノート

反応式

HRID 364448 の反応式
[CH3:1][O:2][N:3]=[C:4]([C:10]([CH3:12])=O)[C:5]([O:7][CH2:8][CH3:9])=[O:6].[C:13]([O:17][C:18]([NH:20][NH2:21])=[O:19])([CH3:16])([CH3:15])[CH3:14]>C(O)C>[CH3:1][O:2][N:3]=[C:4]([C:10](=[N:21][NH:20][C:18]([O:17][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:19])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6]

参加物

4

反応物 2

HCID 43493Ethyl (2Z)-2-methoxyimino-3-oxo-butanoateHCID 70091tert-Butyl carbazate

生成物 1

HCID 54569379Ethyl 2-methoxyimino-3-t-butoxycarbonylhydrazonobutyrate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of ethyl 2-methoxyiminoacetoacetate (a mixture of syn and anti isomers) (34.6 g.) and t-butoxycarbonylhydrazine (26.4 g.) in ethanol (200 ml.) was stirred for 7.5 hours at ambient temperature and allowed to stand overnight to precipitate crystals. The crystals were collected by filtration, washed with ethanol and dried to give ethyl 2-methoxyimino-3-t-butoxycarbonylhydrazonobutyrate (a mixture of syn and anti isomers) (41.7 g.), mp 144° to 145° C.

後処理

  1. waitto stand overnight
  2. customto precipitate crystals
  3. filtrationThe crystals were collected by filtration
  4. washwashed with ethanol
  5. customdried

出典と根拠

ORDレコード
ord-60f08f63b5ad474cbf2ec565976360fb
出典データセット
uspto-grants-1986_08
特許番号
US04604456

反応ノート

読み込み中…