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Sulfuric Acid → N-tert-butylpyrazine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Isobutylene | HCID 8255 | — |
| 反応物 | 2,3-Dicyanopyrazine | HCID 300514 | — |
| 溶媒 | tert-Butanol | HCID 6386 | — |
| 生成物 | N-tert-butylpyrazine-2-carboxamide | HCID 4462842 | — |
| 生成物 | 3-cyano-N-tert-butyl-2-pyrazinecarboxamide | HCID 54209485 | — |
反応手順
A compound having the formula (4) can be obtained as follows. The corresponding 2, 3-dicyano-pyrazine is reacted with tert-butyl alcohol or isobutylene in the presence of sulfuric acid to obtain the corresponding N-tert-butyl-2-pyrazinecarboxamide and/or 3-cyano-N-tert-butyl-2-pyrazinecarboxamide. Then, thus obtained corresponding N-tert-butyl-2-pyrazinecarboxamide and/or 3-cyano-N-tert-butyl-2-pyrazinecarboxamide are hydrolyzed under an alkaline condition.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05734055 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-db920a7cf3b74cdbbcd3ab9ee72edff5 |
| 出典メモ | uspto-grants-1998_03 |