Bromine → 1-(5-Bromopyrimidin-2-yl)piperazine
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[Br:13]Br>Cl>[Br:13][C:5]1[CH:6]=[N:1][C:2]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[N:3][CH:4]=1参加物
4
実験手順
This example serves to illustrate procedure B of Scheme 2. To an ice-cooled solution of 1-(2-pyrimidinyl)piperazine (16.4 g, 0.1 mole) in 1N HCl (100 mL) was added dropwise bromine (15.98 g, 0.1 mole). After stirring at 0° for 0.5 hr, the mixture was heated to 100° until dissipation of the red color had occurred. The mixture is filtered, cooled, made alkaline with 50% NaOH and extracted with ether. The dried extract (MgSO4) was concentrated in vacuo to provide 14.5 g (62%) of product, m.p. 73°-75°.
後処理
- temperaturethe mixture was heated to 100° until dissipation of the red color
- filtrationThe mixture is filtered
- temperaturecooled
- extractionextracted with ether
- extractionThe dried extract (MgSO4)
- concentrationwas concentrated in vacuo
出典と根拠
- ORDレコード
- ord-c3ca85b0010e449b8758d7dfd7ba1914
- 出典データセット
- uspto-grants-1986_08
- 特許番号
- US04605655
反応ノート
読み込み中…