化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → 4-Fluorobenzoic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | p-Fluorotoluene | HCID 9603 | — |
| 触媒 | Cobalt(II) acetate tetrahydrate | HCID 61372 | — |
| 触媒 | Sodium Bromide | HCID 253881 | — |
| 触媒 | Sodium Acetate | HCID 517045 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Fluorobenzoic Acid | HCID 9973 | 86.6% |
反応手順
The test described in Example 1 was repeated using 300 g of p-fluorotoluene, 660 g of acetic acid, 132 g of water, 6 g of cobalt acetate tetrahydrate, 5 g of sodium bromide and 5 g of sodium acetate. In a reaction time of 240 minutes, after conventional work-up, 330.5 g of p-fluorobenzoic acid (86.6% of the theory) was obtained, with a purity of 99.9%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04605757 |
| 出典データセット | uspto-grants-1986_08 |
| ORD ID | ord-1fce89aec2444e30b48c457d6650fca9 |
| 出典メモ | uspto-grants-1986_08 |