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Barium → 4-(1H-Imidazol-2-yl)-pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Barium | HCID 5355457 | — |
| 反応物 | 4-(4,5-dihydro-1H-imidazol-2-yl)pyridine | HCID 11159387 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(1H-Imidazol-2-yl)-pyridine | HCID 316817 | 68.1% |
反応手順
2-(4-pyridyl)-imidazoline (7.0 g, 0.047M) and barium mangnate (52.5 g) in CH2Cl2 (500 ml) were refluxed with stirring for 24 hrs. The reaction mixture was then filtered through diatomaceous earth, washed with methylene chloride and then ethylacetate. The combined filtrates were concentrated and crystallized from ethylacetate-petroleum ether to give 4-(1H-imidazol-2-yl)pyridine (4.7 g, 67% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04605744 |
| 出典データセット | uspto-grants-1986_08 |
| ORD ID | ord-8d2006b4e8cb47d7b5b819625280b916 |
| 出典メモ | uspto-grants-1986_08 |